| Ranking/Team/State | Ranking/Opponent/State | Score |
| No. 1 Mater Dei (California) | No. 171 Servite (California) | W 49-0 |
| No. 2 Bishop Gorman (Nevada) | Arbor View (Nevada) | W forfeit |
| No. 3 Chaminade-Madonna (Florida) | No. 136 Coconut Creek (Florida) | W 35-27 |
| No. 4 IMG Academy (Florida) | Idle | |
| No. 5 Kahuku (Hawaii) | Moanalua (Hawaii) | W 59-0 |
| No. 6 St. John Bosco (California) | No. 78 Santa Margarita | L 42-7 |
| No. 7 St. Thomas Aquinas (Florida) | No. 207 Miramar (Florida) | W 38-6 |
| No. 8 Buford (Georgia) | Collins Hill (Georgia) | W 43-0 |
| No. 9 Duncanville (Texas) | Idle | |
| No. 10 St. Joseph’s Prep (Pennsylvania) | Archbishop Wood (Pennsylvania) | W 62-0 |
| No. 11 Miami Central (Florida) | North Miami Beach (Florida) | W 54-0 |
| No. 12 Columbus (Miami, Florida) | Miami (Florida) | W 44-0 |
| No. 13 Colquitt County (Georgia) | No. 253 Lincoln (Tallahassee, Florida) | W 56-16 |
| No. 14 DeSoto (Texas) | Idle | |
| No. 15 Massillon Washington (Ohio) | No. 31 St. John’s College HS (Washington, DC) | W 28-7 |
| No. 16 Sierra Canyon (California) | Notre Dame (Sherman Oaks, California) | W 34-10 |
| No. 17 Thompson (Alabama) | No. 180 Clay-Chalkville (Alabama) | L 36-33 |
| No. 18 St. Edward (Ohio) | St. Ignatius (Ohio) | W 42-7 |
| No. 19 American Heritage (Plantation, Florida) | No. 55 Cardinal Gibbons (Florida) | W 48-7 |
| No. 20 Mill Creek (Georgia) | Central Gwinnett (Georgia) | W 47-7 |
| No. 21 North Shore (Texas) | No. 240 C.E. King (Texas) | W 42-6 |
| No. 22 Walton (Georgia) | North Paulding (Georgia) | W 44-24 |
| No. 23 Center Grove (Indiana) | Pike (Indiana) | W 48-17 |
| No. 24 Cocoa (Florida) | No. 96 Treasure Coast (Florida) | W 38-0 |
| No. 25 Archbishop Hoban (Ohio) | Walsh Jesuit (Ohio) | W 57-7 |
| No. 26 Corona Centennial (California) | Chaparral (California) | W 58-19 |
| No. 27 Good Counsel (Maryland) | St. Mary’s Ryken (Maryland) | W 42-6 |
| No. 28 McCallie (Tennessee) | No. 74 Baylor (Tennessee) | W 34-31 |
| No. 29 Westlake (Austin, Texas) | Del Valle (Texas) | W 58-0 |
| No. 30 Central (Phenix City, Alabama) | Idle | |
| No. 31 St. John’s College HS (Washington, DC) | No. 15 Massillon Washington (Ohio) | L 28-7 |
| No. 32 Lincoln (San Diego, California) | Madison (San Diego, California) | W 30-0 |
| No. 33 DeMatha (Maryland) | Rock Creek Christian Academy (Maryland) | W 42-0 |
| No. 34 John Curtis (Louisiana) | Holy Cross (Louisiana) | L 42-41 |
| No. 35 Atascocita (Texas) | West Brook (Texas) | W 71-0 |
| No. 36 Liberty (Arizona) | Idle | |
| No. 37 Chandler (Arizona) | Casteel (Arizona) | W 49-28 |
| No. 38 Mount Carmel (Chicago, Illinois) | Brother Rice (Illinois) | W 42-7 |
| No. 39 East St. Louis (Illinois) | Belleville West (Illinois) | W 63-0 |
| No. 40 St. Frances Academy (Maryland) | St. Thomas More (Connecticut) | W 39-0 |
| No. 41 Southlake Carroll (Texas) | Idle | |
| No. 42 Saraland (Alabama) | Foley (Alabama) | W 70-20 |
| No. 43 Aledo (Texas) | The Colony (Texas) | W 60-14 |
| No. 44 Butler (North Carolina) | East Mecklenburg (North Carolina) | W 58-0 |
| No. 45 Bergen Catholic (New Jersey) | No. 172 DePaul Catholic (New Jersey) | W 31-13 |
| No. 46 Serra (San Mateo, California) | St. Francis (Mountain View, California) | W 45-17 |
| No. 47 Carrollton (Georgia) | Idle | |
| No. 48 Edna Karr (Louisiana) | No. 233 Brother Martin (Louisiana) | W 19-7 |
| No. 49 Toledo Central Catholic (Ohio) | St. John’s Jesuit (Ohio) | W 35-7 |
| No. 50 Orange Lutheran (California) | No. 100 JSerra (California) | L 24-14 |
| No. 51 Long Beach Poly (California) | Millikan (Long Beach, California) | W 26-23 OT |
| No. 52 Edgewater (Florida) | Wekiva (Florida) | W 29-22 |
| No. 53 Corner Canyon (Utah) | Copper Hills (Utah) | W 49-7 |
| No. 54 Mission Viejo (California) | Kamehameha Kapalama (Hawaii) | W 34-0 |
| No. 55 Cardinal Gibbons (Florida) | No. 19 American Heritage (Plantation, Florida) | L 48-7 |
| No. 56 Jones (Orlando, Florida) | Idle | |
| No. 57 Basha (Arizona) | Brophy Prep (Arizona) | W 31-13 |
| No. 58 Brownsburg (Indiana) | Zionsville (Indiana) | W 59-21 |
| No. 59 Norland (Florida) | Idle | |
| No. 60 Belleville (Michigan) | Glenn (Michigan) | W 35-7 |
| No. 61 Katy (Texas) | Jordan (Texas) | W 42-35 |
| No. 62 Gainesville (Georgia) | Lanier (Georgia) | W 35-0 |
| No. 63 Oakland (Tennessee) | Siegel (Tennessee) | W 49-7 |
| No. 64 Vandegrift (Texas) | Manor (Texas) | W 51-6 |
| No. 65 Loyola Academy (Illinois) | No. 192 St. Rita (Illinois) | W 21-5 |
| No. 66 Skyridge (Utah) | Lone Peak (Utah) | W 41-15 |
| No. 67 Carlsbad (California) | Mission Hills (California) | W 35-14 |
| No. 68 St. Thomas More (Louisiana) | Denham Springs (Louisiana) | W 35-3 |
| No. 69 Venice (Florida) | Riverview Sarasota (Florida) | W 35-14 |
| No. 70 Destrehan (Louisiana) | Bourgeois (Louisiana) | W 49-0 |
| No. 71 South Oak Cliff (Texas) | Spruce (Texas) | W 63-3 |
| No. 72 Providence Day (North Carolina) | North Raleigh Christian (North Carolina) | W 62-10 |
| No. 73 Highland (Arizona) | Red Mountain (Arizona) | W 25-15 |
| No. 74 Baylor (Tennessee) | No. 28 McCallie | L 34-31 |
| No. 75 Mainland (Florida) | Pine Ridge (Florida) | W 45-0 |
| No. 76 Elder (Ohio) | No. 164 Archbishop Moeller (Ohio) | L 38-7 |
| No. 77 Lipscomb Academy (Tennessee) | No. 229 Christian Brothers College (Missouri) | L 48-21 |
| No. 78 Santa Margarita (California) | No. 6 St. John Bosco (California) | L 42-7 |
| No. 79 De La Salle (California) | McClymonds (California) | W 21-0 |
| No. 80 Folsom (California) | No. 201 Oak Ridge (California) | W 41-21 |
| No. 81 Ben Davis (Indiana) | No. 246 Carmel (Indiana) | W 45-16 |
| No. 82 Lakeland (Florida) | Lake Gibson (Florida) | W 21-0 |
| No. 83 Pickerington North (Ohio) | Westland (Ohio) | W 55-6 |
| No. 84 West (Knoxville, Tennessee) | No. 97 Alcoa (Tennessee) | L 24-7 |
| No. 85 Lake Travis (Texas) | Idle | |
| No. 86 Bixby (Oklahoma) | Southmoore (Oklahoma) | W 66-0 |
| No. 87 Seminole (Sanford, Florida) | No. 112 Apopka (Florida) | W 21-3 |
| No. 88 Saguaro (Arizona) | Centennial (Arizona) | L 31-17 |
| No. 89 Benedictine (Georgia) | New Hampstead (Georgia) | W 39-31 |
| No. 90 Male (Kentucky) | Roncalli (Indiana) | W 43-0 |
| No. 91 South Florence (South Carolina) | Hartsville (South Carolina) | W 49-21 |
| No. 92 Denton Guyer (Texas) | McKinney Boyd (Texas) | W 55-7 |
| No. 93 Grimsley (North Carolina) | Western Guilford (North Carolina) | W 55-0 |
| No. 94 Langston Hughes (Georgia) | Alexander (Georgia) | W 56-0 |
| No. 95 Northwestern (South Carolina) | Lancaster (South Carolina) | W 59-6 |
| No. 96 Treasure Coast (Florida) | No. 24 Cocoa (Florida) | L 38-0 |
| No. 97 Alcoa (Tennessee) | No. 84 West (Knoxville, Tennessee) | W 24-7 |
| No. 98 Imhotep Charter (Pennsylvania) | John Bartram (Pennsylvania) | W 42-0 |
| No. 99 Archbishop Spalding (Maryland) | Pallotti (Maryland) | W 62-0 |
| No. 100 JSerra (California) | No 50 Orange Lutheran (California) | W 24-14 |
| No. 101 Hewitt-Trussville (Alabama) | Huffman (Alabama) | W 62-0 |
| No. 102 Rabun Gap-Nacoochee (Georgia) | Charlotte Christian (North Carolina) | W 28-13 |
| No. 103 St. Augustine (Florida) | Matanzas (Florida) | W 49-9 |
| No. 104 Oak Grove (Mississippi) | Laurel (Mississippi) | W 52-14 |
| No. 105 Bartram Trail (Florida) | Fleming Island (Florida) | W 49-28 |
| No. 106 Armwood (Florida) | Wharton (Florida) | W 27-13 |
| No. 107 Grayson (Georgia) | No. 142 Newton (Georgia) | L 31-27 |
| No. 108 Vero Beach (Florida) | Central (Fort Pierce, Florida) | PPD Monday |
| No. 109 Rome (Georgia) | Woodstock (Georgia) | W 59-7 |
| No. 110 Cibolo Steele (Texas) | Idle | |
| No. 111 Rancho Cucamonga (California) | Idle | |
| No. 112 Apopka (Florida) | No. 87 Seminole (Sanford, Florida) | L 21-3 |
| No. 113 Tampa Bay Tech (Florida) | Freedom (Florida) | W 45-0 |
| No. 114 Weddington (North Carolina) | Idle | |
| No. 115 Creekside (Georgia) | Mays (Georgia) | W 21-20 |
| No. 116 St. Anthony’s (Melville, New York) | Chaminade (New York) | W 20-13 |
| No. 117 Booker T. Washington (Miami, Florida) | Jackson (Miami, Florida) | W 37-0 |
| No. 118 St. Joseph Regional (Montvale, New Jersey) | Donovan Catholic (New Jersey) | W 52-28 |
| No. 119 Archbishop Stepinac (New York) | Cardinal Hayes (New York) | L 33-28 |
| No. 120 Serra (Gardena, California) | No. 236 Chaminade (California) | W 34-7 |
| No. 121 Iona Prep (New York) | Monsignor Farrell (New York) | W 31-20 |
| No. 122 St. Xavier (Kentucky) | Ryle (Kentucky) | W 55-35 |
| No. 123 Lehi (Utah) | Westlake (Utah) | W 31-6 |
| No. 124 Bishop McDevitt (Harrisburg, Pennsylvania) | Milton Hershey (Pennsylvania) | W 55-14 |
| No. 125 American Fork (Utah) | No. 282 Pleasant Grove (Utah) | W 31-10 |
| No. 126 Oaks Christian (California) | Calabasas (California) | W 56-8 |
| No. 127 Cherry Creek (Colorado) | Cherokee Trail (Colorado) | W 48-0 |
| No. 128 Enterprise (Alabama) | Idle | |
| No. 129 Auburn (Alabama) | Ramsay (Alabama) | W 13-7 |
| No. 130 McKinney (Texas) | Braswell (Texas) | W 35-14 |
| No. 131 Lincoln (Gahanna, Ohio) | New Albany (Ohio) | W 20-7 |
| No. 132 Lee County (Georgia) | No. 151 Houston County (Georgia) | W 44-35 |
| No. 133 Zachary (Louisiana) | West Monroe (Louisiana) | W 48-7 |
| No. 134 Parkview (Georgia) | South Gwinnett (Georgia) | W 34-20 |
| No. 135 Longview (Texas) | Idle | |
| No. 136 Coconut Creek (Florida) | No. 3 Chaminade-Madonna (Florida) | L 35-27 |
| No. 137 Pittsburgh Central Catholic (Pennsylvania) | Canon-McMillan (Pennsylvania) | W 49-6 |
| No. 138 Lake Wales (Florida) | Davenport (Florida) | W 50-14 |
| No. 139 Warren Easton (Louisiana) | John Ehret (Louisiana) | W 35-0 |
| No. 140 Ruston (Louisiana) | Nelville (Louisiana) | W 14-10 |
| No. 141 Prosper (Texas) | Little Elm (Texas) | W 51-13 |
| No. 142 Newton (Georgia) | No. 107 Grayson (Georgia) | W 31-27 |
| No. 143 Bryant (Arkansas) | Jonesboro (Arkansas) | W 42-12 |
| No. 144 Westlake (Atlanta, Georgia) | Idle | |
| No. 145 Palmetto (Miami, Florida) | Coral Gables (Florida) | W 35-0 |
| No. 146 North Cobb (Georgia) | Idle | |
| No. 147 Western (Davie, Florida) | Piper (Florida) | W 49-0 |
| No. 148 Milton (Georgia) | Idle | |
| No. 149 Rockwall (Texas) | Horn (Texas) | W 35-31 |
| No. 150 Highland Park (Texas) | Dallas Jesuit (Texas) | W 15-13 |
| No. 151 Houston County (Georgia) | No. 132 Lee County (Georgia) | L 44-35 |
| No. 152 Dripping Springs (Texas) | Johnson (Buda, Texas) | W 62-13 |
| No. 153 Roswell (Georgia) | Blessed Trinity (Georgia) | W 29-19 |
| No. 154 Pittsburg (California) | Los Gatos (California) | W 37-27 |
| No. 155 Avon (Ohio) | Berea-Midpark (Ohio) | W 41-0 |
| No. 156 Glenville (Ohio) | Rhodes (Ohio) | W 42-6 |
| No. 157 St. Augustine (Louisiana) | Jesuit (Louisiana) | L 13-6 |
| No. 158 Lewisville (Texas) | Coppel (Texas) | L 49-28 |
| No. 159 Don Bosco Prep (New Jersey) | St. Peter’s Prep (New Jersey) | W 37-6 |
| No. 160 Crest (North Carolina) | South Point (North Carolina) | W 61-49 |
| No. 161 Valdosta (Georgia) | Idle | |
| No. 162 Westfield (Indiana) | Avon (Indiana) | W 38-14 |
| No. 163 Hamilton Southeastern (Indiana) | Noblesville (Indiana) | W 43-22 |
| No. 164 Archbishop Moeller (Ohio) | No. 76 Elder (Ohio) | W 38-7 |
| No. 165 Timpview (Utah) | Wasatch (Utah) | W 44-7 |
| No. 176 Mansfield Timberview (Texas) | Birdville (Texas) | W 40-21 |
| No. 167 Homestead (Florida) | Idle | |
| No. 168 Gaffney (South Carolina) | Idle | |
| No. 169 Vestavia Hills (Alabama) | Idle | |
| No. 170 Liberty (Nevada) | Desert Pines (Nevada) | W forfeit |
| No. 171 Servite (California) | No. 1 Mater Dei (California) | L 49-0 |
| No. 172 DePaul Catholic (New Jersey) | No. 45 Bergen Catholic (New Jersey) | L 31-13 |
| No. 173 Los Alamitos (California) | Fountain Valley (California) | W 49-10 |
| No. 174 Maury (Virginia) | Norcom (Virginia) | W 68-8 |
| No. 175 North Crowley (Texas) | Idle | |
| No. 176 Catholic (Baton Rouge, Louisiana) | Northside (Lafayette, Louisiana) | W 42-0 |
| No. 177 Highland Springs (Virginia) | Idle | |
| No. 178 Lafayette Christian Academy (Louisiana) | Avoyelles (Louisiana) | W 52-14 |
| No. 179 Hamilton (Arizona) | Perry (Arizona) | W 59-34 |
| No. 180 Clay-Chalkville (Alabama) | No. 17 Thompson (Alabama) | W 36-33 |
| No. 181 Helix (California) | West Hills (California) | W 41-7 |
| No. 182 Pearl-Cohn (Tennessee) | Whites Creek (Tennessee) | W 49-0 |
| No. 183 St. Xavier (Ohio) | No. 209 Trinity (Kentucky) | L 17-3 |
| No. 184 North Gwinnett (Georgia) | Meadowcreek (Georgia) | W 49-14 |
| No. 185 Liberty (Bakersfield, California) | Garces Memorial (California) | W 41-13 |
| No. 186 Christ Presbyterian Academy (Tennessee) | The Webb School (Tennessee) | W 51-0 |
| No. 187 Princeton (Ohio) | Fairfield (Ohio) | W 35-14 |
| No. 188 Parkview (Arkansas) | De Queen (Arkansas) | W 55-7 |
| No. 189 Lake Mary (Florida) | No. 279 Mandarin (Florida) | W 34-16 |
| No. 190 Norcross (Georgia) | Duluth (Georgia) | W 41-14 |
| No. 191 Red Bank Catholic (New Jersey) | Seton Hall Prep (New Jersey) | W 21-16 |
| No. 192 St. Rita (Illinois) | No. 65 Loyola Academy (Illinois) | L 21-5 |
| No. 193 Conway (Arkansas) | North Little Rock (Arkansas) | W 36-7 |
| No. 194 South Pointe (South Carolina) | Catawba Ridge (South Carolina) | W 31-3 |
| No. 195 St. Mary’s (Stockton, California) | Lodi (California) | W 49-0 |
| No. 196 Spartanburg (South Carolina) | No. 260 Byrnes (South Carolina) | L 21-9 |
| No. 197 Manatee (Florida) | Lakewood Ranch (Florida) | W 52-6 |
| No. 198 Wayne (Huber Heights, Ohio) | Northmont (Ohio) | L 26-24 |
| No. 199 Buchholz (Florida) | Idle | |
| No. 200 Lincoln-Way East (Illinois) | Lockport (Illinois) | W 41-0 |
| No. 201 Oak Ridge (California) | No. 80 Folsom (California) | L 41-21 |
| No. 202 Cedar Grove (Georgia) | Idle | |
| No. 203 Melissa (Texas) | Idle | |
| No. 204 Davison (Michigan) | South Lyon (Michigan) | W 44-0 |
| No. 205 Fort Dorchester (South Carolina) | Ashley Ridge (South Carolina) | W 40-22 |
| No. 206 Dillard (Florida) | Boyd Anderson (Florida) | W 7-0 |
| No. 207 Miramar (Florida) | No. 7 St. Thomas Aquinas (Florida) | L 38-6 |
| No. 208 East Central (Indiana) | Connersville (Indiana) | W 64-0 |
| No. 209 Trinity (Kentucky) | No. 183 St. Xavier (Ohio) | W 17-3 |
| No. 210 Cardinal Newman (Florida) | No. 271 Northestern (Miami, Florida) | L 7-2 |
| No. 211 Atlantic (Delray Beach, Florida) | Idle | |
| No. 212 Monarch (Florida) | Olympic Heights (Florida) | W 45-0 |
| No. 213 Centerville (Ohio) | Beavercreek (Ohio) | W 38-6 |
| No. 214 Thomas County Central (Georgia) | Veterans (Georgia) | W 52-0 |
| No. 215 Brentwood (Tennessee) | Franklin (Tennessee) | W 31-17 |
| No. 216 Bishop Chatard (Indiana) | Andrean (Indiana) | W 41-0 |
| No. 217 Lakota West (Ohio) | Oak Hills (Ohio) | W 59-7 |
| No. 218 Cathedral (Indiana) | La Salle (Ohio) | W 39-26 |
| No. 219 Carthage (Texas) | Brownsboro (Texas) | W 45-0 |
| No. 220 Clearwater Central Catholic (Florida) | Carrollwood Day (Florida) | W 28-27 |
| No. 221 Ocean Springs (Mississippi) | Idle | |
| No. 222 De Smet (Missouri) | St. Louis University (Missouri) | W 42-13 |
| No. 223 Westgate (Louisiana) | Calvary Baptist Academy (Louisiana) | L 32-22 |
| No. 224 Picayune (Mississippi) | Idle | |
| No. 225 West Charlotte (North Carolina) | Hopewell (North Carolina) | W 56-20 |
| No. 226 De La Salle Collegiate (Michigan) | St. Francis de Sales (Toledo, Ohio) | W 67-7 |
| No. 227 Mallard Creek (North Carolina) | North Mecklenburg (North Carolina) | W 34-7 |
| No. 228 St. Charles Catholic (Louisiana) | Vandebilt Catholic (Louisiana) | W 30-13 |
| No. 229 Christian Brothers College (Missouri) | No. 77 Lipscomb Academy (Tennessee) | W 48-21 |
| No. 230 Cartersville (Georgia) | Calhoun (Georgia) | W 21-17 |
| No. 231 Byron Nelson (Texas) | Idle | |
| No. 232 Ware County (Georgia) | Idle | |
| No. 233 Brother Martin (Louisiana) | No. 48 Edna Karr (Louisiana) | L 19-7 |
| No. 234 Coffee (Georgia) | Idle | |
| No. 235 Pickerington Central (Ohio) | Central Crossing (Ohio) | W 48-0 |
| No. 236 Chaminade (California) | No. 120 Serra (Gardena, California) | L 34-7 |
| No. 237 Benjamin (Florida) | Glades Central (Florida) | W 48-6 |
| No. 238 Dublin Coffman (Ohio) | Olentangy Orange (Ohio) | L 35-14 |
| No. 239 Brandon (Mississippi) | Idle | |
| No. 240 C.E. King (Texas) | No. 21 North Shore (Texas) | L 42-6 |
| No. 241 Carencro (Louisiana) | New Iberia (Louisiana) | W 55-34 |
| No. 242 Marist (Georgia) | Dunwoody (Georgia) | W 45-7 |
| No. 243 Rockledge (Florida) | No. 252 Trinity Christian Academy (Jacksonville, Florida) | L 19-13 |
| No. 244 Anderson (Ohio) | Little Miami (Ohio) | W 46-20 |
| No. 245 Winton Woods (Ohio) | Kings (Ohio) | W 13-12 |
| No. 246 Carmel (Indiana) | No. 81 Ben Davis (Indiana) | L 45-16 |
| No. 247 Woodward Academy (Georgia) | Lovejoy (Georgia) | W 31-7 |
| No. 248 Raines (Florida) | Riverside (Jacksonville, Florida) | W 26-24 |
| No. 249 Teurlings Catholic (Louisiana) | Breaux Bridge (Louisiana) | W 27-10 |
| No. 250 Louisville (Mississippi) | Houston (Mississippi) | W 50-6 |
| No. 251 Bolles School (Florida) | Episcopal School of Jacksonville (Florida) | W 48-21 |
| No. 252 Trinity Christian Academy (Jacksonville, Florida) | No. 243 Rockledge (Florida) | W 19-13 |
| No. 253 Lincoln (Tallahassee, Florida) | No. 13 Colquitt County (Georgia) | L 56-16 |
| No. 254 Starkville (Mississippi) | Greenwood (Mississippi) | W 49-6 |
| No. 255 Delbarton (New Jersey) | Paramus Catholic (New Jersey) | W 45-0 |
| No. 256 Douglass (Kentucky) | Idle | |
| No. 257 Northwest Rankin (Mississippi) | Idle | |
| No. 258 Germantown (Tennessee) | Whitehaven (Tennessee) | W 35-6 |
| No. 259 Chapman (South Carolina) | Carolina Academy (South Carolina) | W 57-0 |
| No. 260 Byrnes (South Carolina) | No. 196 Spartanburg (South Carolina) | W 21-9 |
| No. 261 Hough (North Carolina) | West Mecklenburg (North Carolina) | W 48-0 |
| No. 262 Dutch Fork (South Carolina) | Idle | |
| No. 263 DuPont Manual (Kentucky) | Idle | |
| No. 264 Rolesville (North Carolina) | Wakefield (North Carolina) | W 58-0 |
| No. 265 American Leadership Academy (Queen Creek, Arizona) | Mountain Pointe (Arizona) | W 28-0 |
| No. 266 Murrieta Valley (California) | Roosevelt (Eastvale, California) | W 56-27 |
| No. 267 Westfield (Texas) | Dekaney (Texas) | W 23-23 |
| No. 268 Warner Robins (Georgia) | Ola (Georgia) | W 28-27 |
| No. 269 Edison (Miami, Florida) | Immaculata LaSalle (Florida) | W 28-0 |
| No. 270 Granite Hills (El Cajon, California) | Santana (California) | W 42-6 |
| No. 271 Northwestern (Miami, Florida) | No. 210 Newman Catholic (Florida) | W 7-2 |
| No. 272 Dickinson (Texas) | Idle | |
| No. 273 Northside (Warner Robins, Georgia) | Tift County (Georgia) | W 35-34 |
| No. 274 Hoover (Alabama) | Mountain Brook (Alabama) | L 34-24 |
| No. 275 Houston (Tennessee) | Bartlett (Tennessee) | W 24-14 |
| No. 276 Ridge Point (Texas) | George Ranch (Texas) | W 55-27 |
| No. 277 Tupelo (Mississippi) | West Point (Mississippi) | L 21-20 |
| No. 278 Fort Bend Hightower (Missouri City, Texas) | Idle | |
| No. 279 Mandarin (Florida) | No. 189 Lake Mary (Florida) | L 34-16 |
| No. 280 San Clemente (California) | Idle | |
| No. 281 Pinnacle (Arizona) | Chaparral (Arizona) | W 47-6 |
| No. 282 Pleasant Grove (Utah) | No. 125 American Fork (Utah) | L 31-10 |
| No. 283 Argyle (Texas) | Idle | |
| No. 284 Trotwood-Madison (Ohio) | Ponitz Career Tech (Ohio) | W 54-6 |
| No. 285 Lambert (Georgia) | Idle | |
| No. 286 East Coweta (Georgia) | Idle | |
| No. 287 Freedom (Woodbridge, Virginia) | Forest Park (Virginia) | W 64-6 |
| No. 288 Sandy Creek (Georgia) | Harris County (Georgia) | L 28-19 |
| No. 289 Campbell (Hawaii) | Idle | |
| No. 290 Punahou (Hawaii) | St. Louis (Hawaii) | W 42-28 |
| No. 291 Gonzaga (Washington, DC) | Friendship Collegiate (Washington, DC) | W 16-13 OT |
| No. 292 Prince Avenue Christian (Georgia) | Mary Persons (Georgia) | L 45-28 |
| No. 293 Jenks (Oklahoma) | Westmoore (Oklahoma) | L 16-12 |
| No. 294 Union (Oklahoma) | Yukon (Oklahoma) | W 63-7 |
| No. 295 Phoebus (Virginia) | Hampton (Virginia) | W 28-6 |
| No. 296 Niceville (Florida) | Crestview (Florida) | W 42-21 |
| No. 297 Edmond Santa Fe (Oklahoma) | Edmond North (Oklahoma) | W 52-17 |
| No. 298 Clovis North (California) | Clovis East (California) | W 31-21 |
| No. 299 Douglas County (Georgia) | New Manchester (Georgia) | W 50-0 |
| No. 300 West Linn (Oregon) | Lake Oswego (Oregon) | W 49-14 |
