The first week of the 2022 season started with most of the favorites opening with wins.
Top-ranked St. Edward received a scare before leaving the field with a 23-20 win over No. 12 Toledo Central Catholic. This week, the Eagles will face Pennsylvania-power Pittsburgh Central Catholic, ranked No. 159 in the High School Football America 300 national rankings, powered by NFL Play Football.
In other intra-Top 25 games:
No. 2 Archbishop Moeller opened with a 49-31 win over Preseason No. 6 Massillon Washington.
No. 4 Lakota West opened with an impressive win inside our Ohio Top 25. The Firebirds trailed No. 10 St. Xavier 13-0 before scoring 16 unanswered points in the second half in a 16-13 win.
Walsh Jesuit moves up two spots to No. 18 after beating Benedictine 21-14. The Bengals, who play Toledo CC this week, drop two spots to No. 20 in the latest rankings.
New Albany also moves two spots from the preseason rankings after shutting-out Preseason No. 19 Marysville 35-0.
New to the Top 25 this week is Centerville at No. 24.
High School Football America Ohio Top 25
| Ranking/Team | Record | Preseason Ranking |
| No. 1 St. Edward | (1-0) | 1 |
| No. 2 Archbishop Moeller | (1-0) | 2 |
| No. 3 Springfield | (0-0) | 3 |
| No. 4 Lakota West | (1-0) | 4 |
| No. 5 Archbishop Hoban | (1-0) | 5 |
| No. 6 Winton Woods | (1-0) | 7 |
| No. 7 Massillon Washington | (0-1) | 6 |
| No. 8 St. Ignatius | (0-0) | 8 |
| No. 9 Pickerington Central | (1-0) | 9 |
| No. 10 St. Xavier | (0-1) | 10 |
| No. 11 La Salle | (1-0) | 11 |
| No. 12 Toledo Central Catholic | (0-1) | 12 |
| No. 13 Chardon | (1-0) | 13 |
| No. 14 Upper Arlington | (1-0) | 14 |
| No. 15 Elder | (1-0) | 15 |
| No. 16 Pickerington North | (1-0) | 16 |
| No. 17 Avon | (1-0) | 17 |
| No. 18 Walsh Jesuit | (1-0) | 20 |
| No. 19 New Albany | (1-0) | 21 |
| No. 20 Benedictine | (0-1) | 18 |
| No. 21 Mentor | (1-0) | 22 |
| No. 22 Princeton | (1-0) | 23 |
| No. 23 Kings | (1-0) | 24 |
| No. 24 Centerville | (1-0) | NR |
| No. 25 Badin | (1-0) | 25 |
Dropped-out: No. 19 Marysville
